Double Cancerand Longevity

Calorie Restriction, Longevity and Cognitive Function

ReviewArticte Epidemiological Studies onthe Distribution Tract Cancerand Determinants of Bil - . Iary Masaharu YAMAMOTO '

With the help ef my co}leagues, I haye been conducting epidemiolegical studies on biliary tract cancer (BTC), ineluding gallbladder cancer (GBC) and extrahepatic bile duct caflcer (BDC), in Japan and Chile for about 19 years. Clustered areas with high mortality rates, especially for female GBC were found to correspond with places or prefectures in Japan that were famous for rice production. The...

Scientific Longevity

We have made use of gene expression analysis of peripheral blood (PB) mononuclear cells to develop expression profiles that accurately reflect prior radiation exposure. We demonstrate that expression profiles can be developed that not only predict radiation exposure in mice but also distinguish the level of radiation exposure, ranging from 50 cGy to 1,000 cGy. Likewise, a molecular signature of...

Homocysteine and Familial Longevity: The Leiden Longevity Study

Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease. We aimed to explore the association of homocysteine with familial longevity by testing whether homocysteine is lower in individuals that are genetically enriched for longe...

Renal function in familial longevity: the Leiden Longevity Study.

Studying renal function in subjects with a familial propensity for longevity may provide insight in (un)known mechanisms that determine the age-related decline in renal function of normal subjects. In the Leiden Longevity Study, middle-aged offspring of non-agenarian siblings and their partners as environmentally matched controls were included. Information was collected on lifestyle, medical hi...